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With gastroesophageal reflux disease, the lower esophageal sphincter relaxes between swallows and after eating, allowing stomach contents and corrosive acid to back up and burn or irritate the lining of the esophagus

Over time, smoking damages cells and DNA, explaining how smoking causes cancer and why the risk increases with longer exposure

Eligibility criteria The inclusion criteria have been formulated according to the components of PICOS (Population, Intervention, Comparison, Outcomes and Study Design)

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This article was co-authored by Florisa-Leila Ramos and by wikiHow staff writer, Ali Garbacz, B.A