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Nicotine is well distributed with a volume of distribution of about 2.6 L/kg [21]

While the science is still out when it comes to just how unhealthy vaping is, the nicotine is no different from the nicotine in a traditional cigarette

By 2030, the cigarette pack as a branding vehicle may be nearly extinct in regulated markets

A clinician or health payer can easily depict smoking-related disease as self-inflicted, similar to alcohol and liver disease or poor diet and obesity and thus punitively restrict access to certain treatment options for these patients accordingly

Manufacturing issues, price hikes, flavor inconsistency and nicotine levels