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20 Like the previous study, this study did not include baseline proteinuria or kidney function as independent variables at study entry

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Direct Toxic Effects of Cigarette Smoke on Intestinal Milieu/Autoimmunity While there is little doubt, as this review has already demonstrated, that smoking is detrimental to treatment outcomes in IBD based on a multitude of observational data, there are remarkably few studies that have explored the underlying mechanisms of which and how particular constituents of tobacco smoking affect the intestinal milieu and/or relevant immune-inflammatory pathways