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The neuropsychiatric safety of CHANTIX was evaluated in a randomized, double-blind, active and placebo-controlled study that included patients without a history of psychiatric disorder (nonpsychiatric cohort, N=3912) and patients with a history of psychiatric disorder (psychiatric cohort, N=4003)

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51 Also, other double-blind and randomized investigation in alcohol-dependent subjects (n = 61) reported that gabapentin treatment (400 mg qid) during 7 d was not better than placebo, in reducing the initial consumption of clomethiazole, or alleviating alcohol acute withdrawal symptoms