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These findings and interpretations are indirectly supported by a recent report on fatigue in the long COVID-19 syndrome where lower peripheral serotonin was observed in patients than in healthy controls ( Peripheral 5-HT is produced and secreted by the enterochromaffin cells in the gastrointestinal tract where it regulates intestinal mobility

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In this trial, we will explore the effect of SAMe supplementation on tau phosphorylation and epigenetics, via measurement of plasma p-tau181 and DNA methylation, respectively, in patients with AD

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