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Peripheral Artery Disease (PAD) most frequently damages the arteries responsible for supplying oxygen to the legs, which is why symptoms typically manifest in the legs before affecting other areas of the body

However, the medication that the article deals with can have different (withdrawal) effects and do not all follow the same neurobiology, but the authors of the article do not provide different guidance for different types of SSRIs

Carlier et al

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It is also important to note that nicotine replacement therapy in the form of tablets or patches has long been recommended as means to help smoking cessation in patients with established CVD (Verbiest et al., Reference Verbiest, Brakema, van der Kleij, Sheals, Allistone and Williams2017)