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But I would advise heavy smokers to start with at least 12 mg regular nicotine, or 30 mg salts (if not something even stronger)

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Here are some risks of using cannabis for IBS symptom management: Increased risks of motor vehicle accidents (remember CBD still has psychoactive effects without it intoxicating you!) Intoxication Nausea or vomiting (with THC or excessive oral intake) Liver disease and fibrosis (especially those with pre-existing liver conditions) Increased risk of cardiac disease Cognitive impairment with acute or excessive use Increased risk of bronchitis (for smoking/vaping) Psychosis (especially in high THC users) Increase in social anxiety for chronic users Risks in those with a history of mental health issues Violent behaviour (synthetic cannabinoids) Suicidal ideation (synthetic cannabinoids) Cannabinoid hyper-emesis syndrome (chronic excessive use) Depression/Anxiety (chronic excessive use) Addiction / Cannabis use disorder Cannabis withdrawal Endocannabinoid System and IBS Symptom Management The endocannabinoid system is present in the GI tract

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Variations could still have an impact on the rate of administration