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New Therapeutic Targets Needed: The commentary highlights the need for innovative approaches and therapeutic targets beyond traditional cessation methods, urging the development of products that consider reductions in smoking as meaningful study endpoints

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Combining a "long-acting" NRT like the nicotine patch with "short-acting" NRTs such as gum, lozenges, nasal sprays, or inhalers can address both the consistent need for nicotine (via the patch) and immediate cravings (via faster-acting forms)