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With repeated smoking, the neurons adapt to this increased electrical activity, and the smoker becomes dependent upon the nicotine

With reduced collagen and elastin, the skin becomes thinner and less able to repair itself

Improved Cardiovascular Health : Smoking accelerates the build-up of plaque in your arteries, contributing to heart disease

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Some cancer germline variants were exclusive to never smokers with lung cancer, suggesting that further research to curate a list of LCNS associated PVs and their penetrance may be clinically relevant for calculation of a combined lung cancer risk score for never smoker patients