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Consequently, hydroxyl radical formation needs transition metals near a critical site to inactivate the biological target [81]

The observational studies ( n 4) included in this review supported associations of lower maternal B 12 and poorer cognitive functions in the child, whereas one RCT showed a beneficial effect of B 12 supplementation on offspring language abilities at 30 months but no effect at 9 months (Reference Behere, Deshmukh and Otiv125) (Table 3)

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It can be induced or exacerbated by HFD, characterized by the consumption of foods rich in saturated fats and cholesterol