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The problem is that no one was actually using nicotine as a drug by itself (without the tobacco) over an extended time period, so there was no way to tell if it was causing cancer in people

Nevertheless, this still remains lower than in 2016-2018

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Possible long-term effects of nicotine Constant urge to have more nicotine Early aging and skin wrinkles Ongoing stomach issues like ulcers Heart attacks and other heart issues Problems with eyesight Changes to how things taste and smell Loss of muscle Problems with focus, memory, and learning Long-term mental health issues like depression and anxiety