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The more severe symptoms in allergic disorders have been associated with mitochondrial defects around complexes I and III, which are responsible for the majority of mtROS production due to electron leakage (85)

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This is especially important for people who previously smoked very little or have gone nicotine-free for a period and are returning

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While natural sources contribute to background levels of CO in the atmosphere, man-made sources are the primary concern for indoor air quality and human health