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Indeed, both GOT1 and GOT2 are overexpressed in KRAS-driven pancreatic ductal adenocarcinoma (PDAC) cells 34,35

Aberrant activation of the coagulation cascade, abnormal excess of TF on the endothelial wall and high plasma levels of different coagulation factors drive increased thrombin and fibrin production leading to further inflammation and risk of VOC (Sundd et al., 2019)

First of all, ferroptosis may be impacted by the overexpression of genes related to iron metabolism, such as HO-1, caused by the activation of HIF-1 in hypoxic environments ( Figure 3 )

These two innovations overcome the absorption bottlenecks of traditional GSH via physical encapsulation and chemical modification, respectively

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