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In 2022 (among all Texas adults), six percent of 18- to 24-year-olds, 12.8 percent of 2544-year-olds, 14.9 percent of 4564-year-olds, and 9.3 percent of adults aged 65 years or older were currently smoking combustible cigarettes

Furthermore, smoking induces vascular vasoconstriction, sinusoidal endothelial dysfunction, and smooth muscle proliferation, leading to hypoxia, capillarization of sinusoids, and further activation of HSCs [18]

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Either way, that unpredictability defeats the purpose of using nicotine pouches as a controlled alternative