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FDA: determined there are no significant safety concerns with prescribing combination nicotine replacement therapy (NRT) or using NRT even if a person is still smoking

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Although cigarette smoke is very complex, consisting of over 4,000 compounds linked to CVD, most studies suggest that carbon monoxide, reactive oxygen species, and nicotine are responsible for the pathogenesis of smoking-induced cardiovascular disorders ( 10 , 11 )

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Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity