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PLoS ONE, 2(3), e322

Large-scale quantitative comparison of plasma transmembrane proteins between two human blood-brain barrier model cell lines, hCMEC/D3 and HBMEC/ci

However, recent evidence challenges this paradigm: some of these interventions achieve effectiveness through pathways independent of weight loss, such as direct immunomodulatory actions (9, 10)

lipid hydroperoxides) as well as increased plasma endotoxin concentrations.27 In a previous study we have investigated the intestinal epithelial barrier function in patients with compensated liver cirrhosis in order to find out whether an increased intestinal permeability may be a risk factor for the progression towards decompensated cirrhosis and observed an increased small intestinal permeability in a subgroup of patients with alcohol-related cirrhosis and an increased large intestinal permeability in the whole group of compensated cirrhotic patients.28 We hypothesized that intestinal oxidative stress is involved in the epithelial barrier dysfunction of patients with compensated liver cirrhosis

Vector-based strategies are at the forefront of this field, but choosing the right vehicle can be challenging given the wide array of viral and non-viral vectors available