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[19] The pouches themselves are made of plant fibers, which allow the nicotine to diffuse out of the pouch when moistened

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With tobacco products, this effect lasts about 30 minutes, and then the arteries recover their normal function

This pro-inflammatory response of epithelial cells to CSE is achieved by altering a variety of signaling pathways involved in cellular activation, primarily protein kinase C (PKC), mitogen-actived protein kinase (MAPK), NFB and activatory protein-1 (AP-1) pathways [102,134,135,136]