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Growth suppression of cells was reversed after repeated exposure of cells to the bidi tobacco extract.[] In an in vivo study in DMBA-initiated hairless mice, increased epidermal mitotic activity, mild epidermal hyperplasia, increase in epidermal, and dermal thickness were induced by a single application of two increasing doses of an aqueous extract of bidi tobacco

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We also found that US adults who reported the use of at least one additional tobacco product other than cigarettes and LCCs were significantly less likely to overestimate nicotine health harms and report incorrect nicotine perceptions than those who only used cigarettes and/or LCCs

Kyriakoudes suspects that the handful of individual inventors who kept pushing towards tobacco alternatives did so out of a genuine belief in harm reduction and desire to help others kick their tobacco habits