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e R 2 indicates change in the R-squared value when including the interaction term in the model (i.e., the change in the percentage of outcome variance explained by the model)

Smoking is associated with several autoimmune diseases such as systemic lupus erythematosus, primary biliary cirrhosis or multiple sclerosis, where similar geneenvironment interactions may exist the knowledge gained from research into these diseases could also help in the understanding of RA

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