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However, Cho and his colleagues found that unmarried adults are more likely to use tobacco products than other marital status including married one [64]

Many epidemiological studies have revealed that frequent use of betel nut is associated with adverse health effects such as oral leukoplakia , white patches that develop in the mouth as a reaction to chronic irritation, and submucous fibrosis , a chronic debilitating disease of the oral cavity characterized by inflammation and the formation of scar tissue in the mouth

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Genetic & Biological Factors Some individuals have naturally higher pain sensitivity or slower inflammatory recovery, a process called central sensitization