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A study of 3D organotypic nasal epithelial culture showed that the impact of IQOS was substantially lower than CS in terms of cytotoxicity, tissue morphology, proinflammatory mediators, ciliary function, transcriptome perturbations, and miRNA expression profiles 59

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Public health officials also were starting to suspect that teen e-cigarette use was associated with higher intention to smoke and one study had concluded that teens who try e-cigarettes are more likely to try other tobacco products, including conventional cigarettes

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