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Repeated exposure to nicotine can alter circuits in the brain involved with stress, learning, and self-restraint

PMID 29540557

The CY 2010 final rule adopted the proposal, with minor adjustments based on public comments, and explained that these minor adjustments were in part due to non-response bias that results when the characteristics of survey respondents differ in meaningful ways, such as in the mix of practices sizes, from the general population (74 FR 61749 through 61750)

Victims are neither captured nor detained, but they could be unreachable