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Each eluent subjected to Gas chromatography-thermal energy analysis (GC-TEA) (Health Canada T-111) for analysis of TSNAs including Nnitrosonornicotine (NNN), 4-[methylnitrosamino]-1-[3- pyridyl]-1-butanone (NNK), N-nitrosoanatabine (NAT) and Nnitrosoanabasine (NAB) [25]

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On the contrary, they are both excreted by the kidney, and in the disease processes, they generally vary in the same way: a rise in blood uric acid is well known as an early sign of renal failure