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Our model is complementary to the work of[10] since it focuses on the detailed biochemical mechanisms by which of APAP is detoxified in the liver under both normal and overdose situations

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All other structural modifications, annotations, and visualizations were performed using PyMOL (v3.1)

Stacking at moderate doses for each compound produces complementary effects that targeting one pathway alone cannot replicate, even at supra-therapeutic doses

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