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Specifically, we used a random intercept in the mixed-effects model to account for the within-study correlation and used a study-specific random slope with respect to the signal to capture between-study heterogeneity

[5] [6] He has four brothers and one sister, [7] and was raised Roman Catholic in what he described as a "lower middle-class or upper working-class" family which emphasised the values of education

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Nicotine itself and tobacco-specific N-nitrosamines are actively involved in the formation of reactive oxygen species (ROS) in the mouth 22,23

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