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However, events of this nature were seen in patients with pre-existing psychiatric diagnoses in a smoking cessation trial [see Warnings and Precautions (5.2)]

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(16.5 x 22.2 cm) Credit Line The Robert Capa and Cornell Capa Archive, Gift of Cornell and Edith Capa, 2010 Accession No

There is substantial evidence that e-cigarette aerosols can induce acute endothelial cell dysfunction, although the long-term consequences and outcomes on these parameters with long-term exposure to e-cigarette aerosol are uncertain