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The article from Prasse et al suggest[s] that chronic nicotine stimulation induced by cigarette smoking promotes macrophage and Langerhans cell accumulation in the lung via an increase in [osteopontin production]. Osteopontin and cellular receptors for nicotine may therefore be new targets for treating smoking related lung disease

"Revealed: how Nazis stubbed out smoking"

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Familiar with revolutions and the ramifications of government takeovers, the Plasencias moved north to Honduras