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Causes of Histamine Intolerance Weak digestion Inflamed intestines Bacterial infections (gut especially) Eating things that harm your gut, such as processed food Food allergies and food intolerances (gluten and cow dairy especially) Microbiome imbalance Nutrient deficiencies Overactive immune system Weakened adrenals (low cortisol) Chronic viral infections Mold exposures Fragrances Mentally stressed Overtraining and high amounts of exercise High estrogen levels Genetics The Genetic Connection to Histamine Intolerance There are two main genes associated with histamine intolerance: DAO and HNMT