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The women were given a commercially available nicotine dose intranasally, and at the same time were injected with a radioactive tracer attached to a molecule which binds to the enzyme aromatase: aromatase, also known as estrogen synthase, is the enzyme responsible for the production of estrogen

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[40] Playboy later reprinted photos from that pictorial issue, with titles such as December 1965s "The Playboy Portfolio of Sex Stars", and January 2000s "Centerfolds of the Century"

The program is funded by the California Department of Public Health and the California Tobacco Prevention Program