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Abbreviations ACE2 Angiotensin-converting enzyme 2 Ang-1-7 Angiotensin 1-7 BALF Bronchoalveolar lavage fluid CAD Cinnamaldehyde CDC US Centers for Disease Control and Prevention CO Carbon monoxide COPD Chronic obstructive pulmonary disease COVID-19 Coronavirus disease 2019 CS Cigarette smoke ENDS Electronic nicotine dispensing systems EVALI e-cigarette or vaping product use-associated lung injury FDA Food and Drug Administration GC-FID Gas chromatography with a flame ionisation detector GCMS Gas chromatography-mass spectrometry GM-CSF Granulocytemacrophage colony-stimulating factor HPLC High performance liquid chromatography HUVEC Human umbilical vein endothelial cells IL Interleukin IFN Interferon KO Knockout LCMS Liquid chromatography-mass spectrometry MCP-1/CCL2 Monocyte chemoattractant protein-1 MMP-9 Matrix metallopeptidase 9 nAChR7 7 Nicotinic acetylcholine receptor NC Nickelchromium alloy NO Nitric oxide PG Propylene glycol RANTES/CCL5 Regulated on activation, normal T cell expressed and secreted ROS Reactive oxygen species SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 SS Stainlesssteel atomizer THC Tetrahydrocannabinol TNF Tumour necrosis factor- WT Wild type Authors' contributions All authors discussed and agreed to the scope of the manuscript and contributed to the development of the manuscript at all stages

Each city pulls the other upward