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The caveats on the well-known Bradford Hill guidelines [117] on causality are laid out in Rothman and Greenland [118], where the relation of magnitude of association (e.g., magnitude of rate ratio) to reliability of causal inference is discussed, giving examples of low rate ratios where causation is accepted (e.g., smoking and cardiovascular disease

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Heavier users can start at 4 mg and taper down when cravings feel more manageable.

The episode follows the crew discovering a time capsule from the year 2015 filled with everyday Earth items