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In the prevention and treatment of HE, probiotics, prebiotics, antibiotics, and FMT can all improve hyperammonemia and endotoxemia by regulating the gut microbiome

Although interest in these compounds has grown within the biohacking and antiaging communities, their applications may also be relevant in orthopaedic recovery

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Due to their lipophilicity, they can cross the BBB and exert powerful antioxidant and free-radical-scavenging activities within the brain tissue227, 228, 229