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In the second stage, we used structural equation modeling (SEM) to estimate the parameters of the hypothesized mediation model of the effect of a ffect on tobacco product use (cigarettes / e-cigarettes) via perceived risk of the product, while adjusting for covariates (gender, age, race/ethnicity, and education)

[158] A 2016 study reported that some e-liquids contained tobacco alkaloids such as nornicotine, anabasine, anatabine, and TSNAs, such as N -nitrosonornicotine (NNN), 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone (NNK), [15] nitrates, and phenol

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Tobacco contains nicotine and additional carcinogens beyond those present in cannabis smoke alone