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Abstract Background Airway epithelium is the first barrier against environmental insults, and epithelial barrier dysfunction caused by cigarette smoke (CS) is particularly relevant to chronic obstructive pulmonary disease (COPD) progression

Symptoms include nausea, vomiting, dizziness, tremors, rapid heartbeat, and, in severe cases, respiratory issues and coma

Because of changes in ICD coding, numerator information has changed over time

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