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For more information on this topic, visit: Australian Government Department of Health and Aged Care Better Health, Victoria Department of Education, Western Australia Department of Health, Western Australia HealthyWA John Hopkins Medicine Lung Foundation Royal Childrens Hospital, Melbourne Telethon Kids Institute World Health Organization

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This may be explained by the possible DNE and GOF effects of non-disruptive mutant p53 proteins that lead to increased proliferation, metastasis and chemo-resistance, whereas disruptive p53 mutations are unlikely to exert DNE and GOF effects [167]