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As already mentioned, biologically active endotoxin present in cigarette smoke could act as an adjuvant in airway sensitization through TLR4 signaling

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Throat Cancer Explained: Where It Starts and How It Spreads Throat cancer begins in the lining of the pharynx or larynx and can spread locally to nearby tissues and lymph nodes, and, in advanced stages, to distant organsmaking early detection and staging critical for effective treatment and survival

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It remains long after the smoking has stopped