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Clinical research suggested doses in the range of 1-10mcg per kilogram of body weight showed efficacy, though most protocols standardized around 4-6mcg/kg for practical application

Nat Rev Dis Prim 6:114

[10] Fumaric acid esters (FAEs) have been used for the treatment of psoriasis for over 20 years in several European countries

For the beta diversity analyses, an analysis of similarities (ANOSIM) was performed on each of the distance/dissimilarity matrices to establish whether observed clustering by treatment group was statistically significant

These findings remain preliminary and are based on preclinical or in-vitro research systems