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At 3 months, 59% of the MPT group reported moderate or marked improvement compared to 26% in the GTM group a statistically significant difference

inflammation at an injury site releases a cascade of chemical messengers that effectively 'call' for help

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They are firing in response to stimuli that normally would not trigger a strong signal

Across GLP-1 trials, about 60% of lost weight returns within the first year and roughly 75% returns over the longer curve, with the fastest regain in the early months. In semaglutides extension, about two-thirds returned within one year. The pattern reflects removal of appetite suppression after major weight loss