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Step 5Compute operating and capital outlier threshold (CMS applies a geographic adjustment to the operating and capital outlier threshold to account for local cost variation): Operating CCR to Total CCR = (Operating CCR)/(Operating CCR + Capital CCR) Operating Outlier Threshold = [Fixed Loss Threshold ((Labor-Related Portion CBSA Wage Index) + Nonlabor-Related portion)] Operating CCR to Total CCR + Federal Payment with IME, DSH + Uncompensated Care Payment + supplemental payment for eligible IHS/Tribal hospitals and Puerto Rico hospitals + New Technology Add-On Payment Amount Capital CCR to Total CCR = (Capital CCR)/(Operating CCR + Capital CCR) Capital Outlier Threshold = (Fixed Loss Threshold Geographic Adjustment Factor Capital CCR to Total CCR) + Federal Payment with IME and DSH Step 6Compute operating and capital outlier payments: Marginal Cost Factor = 0.80 or 0.90 (depending on the MS-DRG) Operating Outlier Payment = (Operating CostsOperating Outlier Threshold) Marginal Cost Factor Capital Outlier Payment = (Capital CostsCapital Outlier Threshold) Marginal Cost Factor The payment rate may then be further adjusted for hospitals that qualify for a low-volume payment adjustment under section 1886(d)(12) of the Act and 42 CFR 412.101(b)

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After completing 8 weeks, enter a 2-month rest phase before repeating the cycle

doi: 10.1016/j.cmet.2015.09.025 32 ZengYJiangHZhangXXuJWuXXuQet al

Since GSH is a critical cofactor for GPX4, this depletion directly impairs GPX4 activity, rendering airway epithelial cells and alveolar macrophages highly susceptible to ferroptosis following oxidative insults such as CS exposure ( 2.1.2 System Xc- (SLC7A11) The cystine/glutamate antiporter System Xc- is a key regulator of cellular redox balance and antioxidant defense ( - reinforces cellular defenses against oxidative damage, making it a key target for modulating ferroptosis in COPD