Genetic inhibition or the targeted inhibitor of IGF-2, lincitinib, markedly enhances the response to immune checkpoint blockade, suggesting the potential of IGF-2 as a biomarker and therapeutic target in immunotherapy (141)
Aurora said Id notice a difference, and yep, totally do
It does not promote GH synthesis, so pairing it with a GHRH (e.g., CJC-1295, Sermorelin, Tesamorelin) is essential for full GH-axis stimulation Works best with consistent use over a period of time (chronic dosing has shown more stable results compared to short bursts)
Unfortunately, it's been too little too late
In HNSCC, HGF is majorly secreted via tumor-associated fibroblasts (TAFs) in the tumor microenvironment [80, 81]