The mechanism is sound: restore GHRH signaling, raise GH and IGF-1, shift fat metabolism toward lipolysis in the visceral depots, and improve downstream metabolic markers
Drosophila studies showed 11-16% extension Telomerase activation: In vitro studies confirmed hTERT upregulation in human fetal fibroblasts and pulmonary cells, with treated cells exceeding the Hayflick limit by approximately 10 additional population doublings Telomere elongation: Direct measurements showed statistically significant telomere lengthening in treated cells Cancer incidence: Long-term animal studies showed reduced spontaneous tumor formation, partially addressing the telomerase-cancer concern 2025 validation: An independent study confirmed telomere-lengthening effects across multiple human cell lines, representing the first significant non-Khavinson replication Key limitations: The evidence base is dominated by a single research group
A follow-up cohort study further demonstrated that this association is partly mediated by low-grade systemic inflammation, highlighting inflammation as a mechanistic link between chronic NSW and IBS risk 155
1994) in the respiratory quotient, concluding that L-carnitine does not affect muscle glycogen metabolism
Larger, controlled trials are needed
