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After statistical consultation, the sample size was increased to n = 320 and the study population was divided into three groups: Group 1 (non-smoking patients), Group 2 (smokers with or without additional e-cigarette and/or hookah consumption) and Group 3 (exclusive e-cigarette and/or hookah consumption)

4 Discussion The growing use of e-cigarettes among children and adolescents represents a new and urgent public health challenge