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Early AD involves iron accumulation in cortical and hippocampal areas (112), which disrupts iron homeostasis by altering key regulators: TfR1 and DMT1 decrease, while ferritin, ferroportin 1, and APP increase (113, 114)

doi: 10.1371/journal.ppat.1000494 39 ChongSZWongKLLinGYangCMWongSCAngeliVet al

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