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Recent research further demonstrates that CAT suppresses Hypoxia-inducible factor-2 alpha (HIF-1) expression via activation of solute carrier family 2 member 1 (SLC2A1), effectively reducing ferroptosis-dependent chondrocyte damage and mitigating OA progression (Guan et al., 2023)

Research from the National Cancer Institute has documented several potential mechanisms by which IV vitamin C may affect cancer cells: Phase I clinical trials at medical institutions including the University of Iowa and Thomas Jefferson University have demonstrated safety and potential benefits when HDIVC is administered alongside standard chemotherapy for various cancer types

This observation is indirectly supported by another study involving kidney transplant recipients, where the carriers of rs55754655 required a higher dose of azathioprine to maintain immunosuppressive effect at 3, 6, and 12 months after transplantation ( The transmembrane transporters have also been shown to regulate the intracellular levels of 6-TGN