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Adv Parasitol (2004) 58:168

This first-pass mechanism of periportal toxicity for selected compounds, including hepatotoxicants that primarily affect centrilobular hepatocytes, could result from deficient cytoprotective capacity secondary to depletion of phase II conjugating enzymes in addition to being a consequence of a higher exposure gradient to these upstream hepatocytes

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Most patients can return to their normal routine immediately after the injection, making it a convenient treatment option

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