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In fact, a B12 deficiency can sometimes lead to weight loss due to reduced appetite

Long term prescription of medications such as the following are likely to increase the cause of, or exacerbate the risk of B12 deficiency - the proton pump inhibitors (esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole), famotidine, ranitidine, metformin, glibenclamide, gliclazide, glimepiride, glipizide, sodium valproate, gabapentin, doxycycline, some oral contraceptives

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Injectable B12 has few direct drug interactions, but certain medications can interfere with B12 absorption or measurement: Chloramphenicol: This antibiotic may antagonise the haematological response to B12 in some patients, potentially preventing the expected rise in red blood cell count

These independent studies exist