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Chen MS, Wang SF, Hsu CY, Yin PH, Yeh TS, Lee HC, et al

has reported that iridoid glycosides reduce cardiomyocyte apoptosis and improve ECG parameters in myocardial infarction models (92)

Therefore, it is a safe skincare ingredient, even for people with sensitive skin

FDA (2014)

"Interaction of Bmal1 and eIF2/ATF4 pathway was involved in Shuxie compound alleviation of circadian rhythm disturbance-induced hepatic endoplasmic reticulum stress." J Ethnopharmacol