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The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis

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10.1038/s41422-020-00441-1 56

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The activation of TGR5 further initiates SRC/YAP signaling pathways that support the renewal and proliferation of intestinal stem cells (ISC) while inhibiting the inflammatory vesicle phosphorylation and ubiquitination of NLRP3 in macrophages as well as exerting protection against gut barrier function[68]