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In hypertension, GAS5 is significantly downregulated in endothelial cells (ECs) and VSMCs, and its silencing exacerbates vascular remodeling, increases capillary leakage, and promotes endothelial dysfunction by modulating -catenin signaling
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1.1 Molecular and enzymatic properties of mammalian CHAC enzymes In humans, the CHAC1 gene encodes six transcripts, which give rise to three different isoforms: isoform A, isoform B and isoform X1
For the best performance, typical imaging time should be 6 cells were analysed for each imaging experiment, and all the imaging experiments were repeated at least twice with one set of representative data shown in each figure