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The RRP consists of a small fraction of total vesicles that are physically docked at the active zone, molecularly primed by active zone proteins (such as RIM and Munc13) into a SNARE-assembled, fusion-competent state (Kaeser and Regehr, 2017)

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The copper component of the complex serves as an essential cofactor for lysyl oxidase, an enzyme that catalyzes the cross-linking of tropoelastin molecules into functional elastic fibers with the mechanical properties required for tissue resilience

Women often experience worsening MCAS symptoms around their menstrual cycle, during pregnancy, or in perimenopause

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